Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of a VHL-/- human renal cancer cell line 786-0 transfected with 3 vectors


ABSTRACT: The human renal cancer cell line 786-0 was transfected with 3 vectors allowing the doxycycline-inducible expression of 1) the full length wild type sequence of VHL: 786-0 VHL WT, VHL+/+, 2) the R167Q mutant : 786-0 R167Q, VHL mutated, 3) the empty vector : 786-0 EV, VHL-/-. The aim of the study was to examine whether the VHL-R167Q mutation, which is associated with a high risk of developping clear cell renal carcinomas, could impact the plasticity of renal carcinoma cells.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Stéphanie BUART 

PROVIDER: E-MTAB-11168 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The Most Common <i>VHL</i> Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation.

Buart Stéphanie S   Terry Stéphane S   Diop M'boyba Khadija MK   Dessen Philippe P   Couvé Sophie S   Abdou Abdérémane A   Adam Julien J   Thiery Jérôme J   Savagner Pierre P   Chouaib Salem S  

Cancers 20210802 15


Von Hippel-Lindau <i>disease</i> (<i>VHL</i>) is a rare hereditary syndrome due to mutations of the <i>VHL</i> tumor suppressor gene. Patients harboring the R167Q mutation of the <i>VHL</i> gene have a high risk of developing ccRCCs. We asked whether the R167Q mutation with critical aspects of pseudo-hypoxia interferes with tumor plasticity. For this purpose, we used wild-type <i>VHL</i> (WT-VHL) and VHL-R167Q reconstituted cells. We showed that WT-VHL and VHL-R167Q expression had a similar effe  ...[more]

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