Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NovaSeq 6000
ORGANISM(S): Homo sapiens
SUBMITTER: Stéphanie BUART
PROVIDER: E-MTAB-11168 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Buart Stéphanie S Terry Stéphane S Diop M'boyba Khadija MK Dessen Philippe P Couvé Sophie S Abdou Abdérémane A Adam Julien J Thiery Jérôme J Savagner Pierre P Chouaib Salem S
Cancers 20210802 15
Von Hippel-Lindau <i>disease</i> (<i>VHL</i>) is a rare hereditary syndrome due to mutations of the <i>VHL</i> tumor suppressor gene. Patients harboring the R167Q mutation of the <i>VHL</i> gene have a high risk of developing ccRCCs. We asked whether the R167Q mutation with critical aspects of pseudo-hypoxia interferes with tumor plasticity. For this purpose, we used wild-type <i>VHL</i> (WT-VHL) and VHL-R167Q reconstituted cells. We showed that WT-VHL and VHL-R167Q expression had a similar effe ...[more]