Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Single-cell profiling of the leukemic and non-leukemic immune cell compartments in CD8+ T-cell Large Granular Lymphocytic Leukemia


ABSTRACT: We performed a detailed and precise characterisation of the clonally expanded leukemic cells in CD8+ T-cell Large Granular Lymphocytic Leukemia (T-LGLL). By combining scRNA+TCRαβ-seq with bulk RNA sequencing data we showed evidence of a strong antigen-driven immune response that shapes the entire immune cell repertoire in T-LGLL. Our study highlights how the whole immune cell repertoire including the hyperexpanded CD8+ T-LGLL cells, the non-leukemic CD8+ cells, CD4+ cells, and monocytes contribute to the CD8+ T-LGLL disease phenotype. The raw data for this study have been deposited to the controlled-access archive EGA under EGAS00001005297.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Jani Huuhtanen 

PROVIDER: E-MTAB-11170 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2021-03-24 | E-MTAB-9969 | biostudies-arrayexpress
| EGAS00001005297 | EGA
2024-04-10 | E-MTAB-13419 | biostudies-arrayexpress
2023-03-01 | GSE218355 | GEO
2022-01-01 | E-MTAB-11229 | biostudies-arrayexpress
2023-02-10 | PXD033392 | Pride
| PRJNA881262 | ENA
2023-01-19 | E-MTAB-12523 | biostudies-arrayexpress
2020-04-12 | E-MTAB-8911 | biostudies-arrayexpress
2023-03-30 | E-MTAB-11710 | biostudies-arrayexpress