IGR_Raslova_LMMC
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Guillaume Meurice
PROVIDER: E-MTAB-1121 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.
Antony-Debré Iléana I Bluteau Dominique D Itzykson Raphael R Baccini Véronique V Renneville Aline A Boehlen Françoise F Morabito Margot M Droin Nathalie N Deswarte Caroline C Chang Yunhua Y Leverger Guy G Solary Eric E Vainchenker William W Favier Rémi R Raslova Hana H
Blood 20120607 13
RUNX1 gene alterations are associated with acquired and inherited hematologic malignancies that include familial platelet disorder/acute myeloid leukemia, primary or secondary acute myeloid leukemia, and chronic myelomonocytic leukemia. Recently, we reported that RUNX1-mediated silencing of nonmuscle myosin heavy chain IIB (MYH10) was required for megakaryocyte ploidization and maturation. Here we demonstrate that runx1 deletion in mice induces the persistence of MYH10 in platelets, and a simila ...[more]
Similar Datasets
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2024-05-31 | E-MTAB-14072 | biostudies-arrayexpress
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2014-04-04 | E-MTAB-2089 | biostudies-arrayexpress
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2012-02-13 | E-GEOD-31600 | biostudies-arrayexpress
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