Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

IGR_Raslova_LMMC

ABSTRACT: Characterization of genetic alterations in monocoyte lineage (CD14+ cells) of two CMML (Chronicle Myelo-Monocytic Leukemia) patients. Previously we have shown that RUNX1 downregulates MYH10 expression in megacaryocyte lineage leading in MYH10 overexpression in platelets of patients wiht RUNX1 genetic alterations. MYH10 overexpression could be thus useful as a rapid test of RUNX1 alterations. In these two CMML patients, MYH10 is overexpressed in their platelets but no RUNX1 mutations were detected. The CGH array could evidence not only the large RUNX1 deletion (not detected by sequencing) but also potential deletions in other regulators of MYH10 which are present in the same regulator complex (such FLI1).

ORGANISM(S): Homo sapiens

SUBMITTER: Guillaume Meurice

PROVIDER: E-MTAB-1121 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.

Antony-Debré Iléana I Bluteau Dominique D Itzykson Raphael R Baccini Véronique V Renneville Aline A Boehlen Françoise F Morabito Margot M Droin Nathalie N Deswarte Caroline C Chang Yunhua Y Leverger Guy G Solary Eric E Vainchenker William W Favier Rémi R Raslova Hana H

Blood 20120607 13

RUNX1 gene alterations are associated with acquired and inherited hematologic malignancies that include familial platelet disorder/acute myeloid leukemia, primary or secondary acute myeloid leukemia, and chronic myelomonocytic leukemia. Recently, we reported that RUNX1-mediated silencing of nonmuscle myosin heavy chain IIB (MYH10) was required for megakaryocyte ploidization and maturation. Here we demonstrate that runx1 deletion in mice induces the persistence of MYH10 in platelets, and a simila ...[more]

PMID: 22677128

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Dataset Information

IGR_Raslova_LMMC

Publications

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.

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