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Gene Expression in whole bone from mineralizing osteoblast specific androgen receptor male mice

ABSTRACT: Gene expression profiles were examined in mineralizing-osteoblast specific androgen receptor knockout (mOBL-ARKO) and WT male mice to identify genes regulated by the AR in mineralizing osteoblasts and osteocytes.

ORGANISM(S): Mus musculus

SUBMITTER: Rachel Davey

PROVIDER: E-MTAB-1123 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of gene pathways altered by deletion of the androgen receptor specifically in mineralizing osteoblasts and osteocytes in mice.

Russell Patricia K PK Clarke Michele V MV Skinner Jarrod P JP Pang Tammy P S TP Zajac Jeffrey D JD Davey Rachel A RA

Journal of molecular endocrinology 20120529 1

Androgens play a key role in skeletal growth and maintenance in males and can mediate their actions, at least in part, via the androgen receptor (AR) in osteoblasts. To investigate the mechanisms by which androgens exert their effects via the AR in mineralizing osteoblasts and osteocytes, we identified gene targets/pathways regulated by the AR using targeted gene expression and microarray approaches on bone isolated from mice in which the AR is specifically deleted in mineralizing osteoblasts an ...[more]

PMID: 22525354

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