Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): osteosarcoma
SUBMITTER: Marco Galasso
PROVIDER: E-MTAB-1136 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jones Kevin B KB Salah Zaidoun Z Del Mare Sara S Galasso Marco M Gaudio Eugenio E Nuovo Gerard J GJ Lovat Francesca F LeBlanc Kimberly K Palatini Jeff J Randall R Lor RL Volinia Stefano S Stein Gary S GS Croce Carlo M CM Lian Jane B JB Aqeilan Rami I RI
Cancer research 20120220 7
Osteosarcoma remains a leading cause of cancer death in adolescents. Treatment paradigms and survival rates have not improved in two decades. Driving the lack of therapeutic inroads, the molecular etiology of osteosarcoma remains elusive. MicroRNAs (miRNAs) have demonstrated far-reaching effects on the cellular biology of development and cancer. Their role in osteosarcomagenesis remains largely unexplored. Here we identify for the first time an miRNA signature reflecting the pathogenesis of oste ...[more]