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Naive-cd25 profiling

ABSTRACT: Naive T cell subsets in humans defined by CD25 expression

ORGANISM(S): Homo sapiens

SUBMITTER: Richard Coulson

PROVIDER: E-MTAB-1138 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.

Pekalski Marcin L ML Ferreira Ricardo C RC Coulson Richard M R RM Cutler Antony J AJ Guo Hui H Smyth Deborah J DJ Downes Kate K Dendrou Calliope A CA Castro Dopico Xaquin X Esposito Laura L Coleman Gillian G Stevens Helen E HE Nutland Sarah S Walker Neil M NM Guy Catherine C Dunger David B DB Wallace Chris C Tree Timothy I M TI Todd John A JA Wicker Linda S LS

Journal of immunology (Baltimore, Md. : 1950) 20130215 6

As the thymus involutes with age, the maintenance of peripheral naive T cells in humans becomes strongly dependent on peripheral cell division. However, mechanisms that orchestrate homeostatic division remain unclear. In this study we present evidence that the frequency of naive CD4 T cells that express CD25 (IL-2 receptor α-chain) increases with age on subsets of both CD31(+) and CD31(-) naive CD4 T cells. Analyses of TCR excision circles from sorted subsets indicate that CD25(+) naive CD4 T ce ...[more]

PMID: 23418630

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