Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NovaSeq 6000, Hamamatsu Nanozoomer S60
ORGANISM(S): Homo sapiens
SUBMITTER: Elo Madissoon
PROVIDER: E-MTAB-11640 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Madissoon Elo E Oliver Amanda J AJ Kleshchevnikov Vitalii V Wilbrey-Clark Anna A Polanski Krzysztof K Richoz Nathan N Ribeiro Orsi Ana A Mamanova Lira L Bolt Liam L Elmentaite Rasa R Pett J Patrick JP Huang Ni N Xu Chuan C He Peng P Dabrowska Monika M Pritchard Sophie S Tuck Liz L Prigmore Elena E Perera Shani S Knights Andrew A Oszlanczi Agnes A Hunter Adam A Vieira Sara F SF Patel Minal M Lindeboom Rik G H RGH Campos Lia S LS Matsuo Kazuhiko K Nakayama Takashi T Yoshida Masahiro M Worlock Kaylee B KB Nikolić Marko Z MZ Georgakopoulos Nikitas N Mahbubani Krishnaa T KT Saeb-Parsy Kourosh K Bayraktar Omer Ali OA Clatworthy Menna R MR Stegle Oliver O Kumasaka Natsuhiko N Teichmann Sarah A SA Meyer Kerstin B KB
Nature genetics 20221221 1
Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the human lung, but their spatial context is less well defined. To (re)define tissue architecture of lung and airways, we profiled five proximal-to-distal locations of healthy human lungs in depth using multi-omic single cell/nuclei and spatial transcriptomics (queryable at lungcellatlas.org ). Using computational data integration and analysis, we extend beyond the suspension cell paradigm and discover macro ...[more]