Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration
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ABSTRACT: To identify disease-specific transcriptional programs in retinal pigment epithelium (RPE) cells, fibroblasts from 43 patients with geographic atrophy (GA) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into RPE and compared to those from 36 healthy individuals. 127,659 RPE cells were profiled via single cell RNA-sequencing (scRNA-seq) and cell classification identified 7 cellular states related to RPE maturation.
INSTRUMENT(S): Illumina NovaSeq 6000
ORGANISM(S): Homo sapiens
SUBMITTER: Anne Senabouth
PROVIDER: E-MTAB-11642 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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