Project description:We investigated the regions that are occupied by deltaNp63 in BxPC-3 and L3.6pl and identification of super enhancers in different pancreatic cancer cell lines. Thereby, we identified a group of 45 super enhancers that are associated with poorer prognosis and are highly dependent on deltaNp63.
Project description:Evaluation of interaction frequency in parental L3.6pl cells, paclitaxel-resistant cells and resistant cells treated with a CDK9 inhibitor
Project description:Identification of localization patterns for different histone modifications and transcription activators in parental and resistant cells
Project description:Investigation of gene expression profile changes upon down regulation of p63 in L3.6pl and BxPC-3 cell lines which are representative of the squamous molecular subtype in pancreatic cancer