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WNT activation and TGFβ-smad inhibition potentiate stemness of mammalian auditory neuroprogenitors for high throughput generation of functional auditory neurons in vitro

ABSTRACT: We have previously identified and characterized the phoenix auditory neuroprogenitors (ANPGs) as highly proliferative progenitor cells isolated from the A/J mouse cochlea. In the present study, we aimed at identifying signaling pathways responsible for the intrinsic high stemness of phoenix ANPGs. A transcriptomic comparison of traditionally low stemness ANPGs, isolated from C57Bl/6 and A/J mice at early passages, and high stemness phoenix ANPGs was performed.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Francis Rousset

PROVIDER: E-MTAB-11869 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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