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RNA-seq of human hepatic arteries in a study of primary sclerosing cholangitis

ABSTRACT: PSC is a chronic inflammatory condition of the biliary tree causing biliary strictures and fibrosis and predisposes to cholangiocarcinoma. Traditionally it is considered a primary disorder of the bile duct epithelia. Here we investigate whether injury to the arterial blood supply may contribute to PSC. Hepatic arteries were collected from 8 patients at the time of liver transplantation: 4 with PSC and 4 disease controls. Samples were used for RNA-sequencing, differential expression and pathways analyses.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Perla Troncoso-Rey

PROVIDER: E-MTAB-11917 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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