Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of LSC-like, non-LSC and Mature populations from human AML patient samples


ABSTRACT: Acute myeloid leukemia (AML) is a highly heterogeneous disease and reliable detection of leukemic stem cells (LSCs) across genetic subclasses has proven difficult. We aimed to transcriptionally characterize LSCs specifically in monocyte-like AML (Mono-AML) and and primitive-like AML (Prim-AML) samples using cell surface markers. We used CD64+CD11b+ to define Mature blasts and labelled the rest as Immature. To further enrich for LSC-like cells in the Immature blasts in both Mono- and Prim-AML samples, we included GPR56, a marker for LSCs. We performed RNA sequencing on the FACS-sorted LSC-like and Mature cells from 23 AML patients.

INSTRUMENT(S): NextSeq 550

ORGANISM(S): Homo sapiens

SUBMITTER: Aino-Maija Leppä 

PROVIDER: E-MTAB-11976 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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