Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Histone H3, lysine 27 acetylation ChIP-seq in NALM6 expressing ETV6-RUNX1


ABSTRACT: ETV6-RUNX1 is a fusion protein bringing together almost the entire coding sequence of RUNX1, including the DNA binding runt domain, and the N-terminus of ETV6 which is known to include transcriptional repressors including histone deacetylation 3 (HDAC3). Here we perform ChIP-seq for the active chromatin mark H3K27ac in the NALM6 B-cell acute lymphoblastic leukaemia cell line expressing ETV6-RUNX1 or mutant derivatives of ETV6-RUNX1: Delta helix-loop-helix (dHLH) is a deletion of the pointed domain; R139G is a point mutation in the runt DNA-binding domain.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: Jason Wray 

PROVIDER: E-MTAB-12207 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2022-10-31 | E-MTAB-12209 | biostudies-arrayexpress
2022-10-31 | E-MTAB-12208 | biostudies-arrayexpress
2022-04-01 | GSE176084 | GEO
2020-12-19 | GSE117684 | GEO
2013-11-04 | E-GEOD-50730 | biostudies-arrayexpress
2013-11-04 | E-GEOD-50733 | biostudies-arrayexpress
2015-07-03 | E-GEOD-70495 | biostudies-arrayexpress
2014-08-22 | E-GEOD-60589 | biostudies-arrayexpress
2013-05-27 | E-GEOD-45377 | biostudies-arrayexpress
2021-11-04 | PXD018305 | Pride