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Centenarians up-regulate the expression of microRNAs

ABSTRACT: microRNA analysis

ORGANISM(S): Homo sapiens

SUBMITTER: Eva Serna

PROVIDER: E-MTAB-1231 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Centenarians, but not octogenarians, up-regulate the expression of microRNAs.

Serna Eva E Gambini Juan J Borras Consuelo C Abdelaziz Kheira M KM Belenguer Angel A Sanchis Paula P Avellana Juan A JA Rodriguez-Mañas Leocadio L Viña Jose J

Scientific reports 20121211

Centenarians exhibit extreme longevity and a remarkable compression of morbidity. They have a unique capacity to maintain homeostatic mechanisms. Since small non-coding RNAs (including microRNAs) are implicated in the regulation of gene expression, we hypothesised that longevity of centenarians may reflect alterations in small non-coding RNA expression. We report the first comparison of microRNAs expression profiles in mononuclear cells from centenarians, octogenarians and young individuals resi ...[more]

PMID: 23233880

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