Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Raquel Almeida
PROVIDER: E-MTAB-1234 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pereira Bruno B Sousa Sofia S Barros Rita R Carreto Laura L Oliveira Patrícia P Oliveira Carla C Chartier Nicolas T NT Plateroti Michelina M Rouault Jean-Pierre JP Freund Jean-Noël JN Billaud Marc M Almeida Raquel R
Nucleic acids research 20130213 7
The homeobox transcription factor CDX2 plays a crucial role in intestinal cell fate specification, both during normal development and in tumorigenic processes involving intestinal reprogramming. The CDX2 regulatory network is intricate, but it has not yet been fully uncovered. Through genome-wide screening of a 3D culture system, the RNA-binding protein MEX3A was identified as putatively involved in CDX2 regulation; therefore, its biological relevance was addressed by setting up cell-based assay ...[more]