Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Single-cell characterization of anti-LAG3+anti-PD1 treatment in melanoma patients

ABSTRACT: We evaluated blood samples from 6 patients with metastatic melanoma treated with anti-LAG3+anti-PD1 (160+480 mg) in a phase I trial (NCT01968109) using single-cell RNA and T cell receptor (TCR) sequencing (scRNA+TCRαβ-seq, 10X 5') combined with other multiomics profiling (flow, cytokine, TCRb-seq) from a larger cohort of 40 patients. This data set include three time points, including baseline, 1 month, and 3 month. The sorting is CD45+.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Jani Huuhtanen

PROVIDER: E-MTAB-12733 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma.

Huuhtanen Jani J Kasanen Henna H Peltola Katriina K Lönnberg Tapio T Glumoff Virpi V Brück Oscar O Dufva Olli O Peltonen Karita K Vikkula Johanna J Jokinen Emmi E Ilander Mette M Lee Moon Hee MH Mäkelä Siru S Nyakas Marta M Li Bin B Hernberg Micaela M Bono Petri P Lähdesmäki Harri H Kreutzman Anna A Mustjoki Satu S

The Journal of clinical investigation 20230315 6

BackgroundRelatlimab plus nivolumab (anti-lymphocyte-activation gene 3 plus anti-programmed death 1 [anti-LAG-3+anti-PD-1]) has been approved by the FDA as a first-line therapy for stage III/IV melanoma, but its detailed effect on the immune system is unknown.MethodsWe evaluated blood samples from 40 immunotherapy-naive or prior immunotherapy-refractory patients with metastatic melanoma treated with anti-LAG-3+anti-PD-1 in a phase I trial using single-cell RNA and T cell receptor sequencing (scR ...[more]

PMID: 36719749

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Dataset Information

Single-cell characterization of anti-LAG3+anti-PD1 treatment in melanoma patients

Publications

Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma.

Similar Datasets

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