Impact of embryonically-derived Kupffer cells depletion on liver gene expression under hypercholesterolemic conditions
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ABSTRACT: Kupffer cells (KCs) are the tissue resident macrophage population of the liver. With this experiment, we sought to investigate the potential consequences of decreasing embryonically-derived KC numbers on liver gene expression in the context of hypercholesterolemia. 3-month-old CD207-DTR x LDL-receptor deficient (C57BL6J background) female mice were injected with diphtheria toxin (DT) or heat-inactivated DT. Mice were then fed a cholesterol-rich diet to induce hypercholesterolemia. RNA sequencing was performed on liver RNA samples after 4 weeks of diet.
INSTRUMENT(S): Illumina NovaSeq 6000
ORGANISM(S): Mus musculus
SUBMITTER: Dussaud Sebastien
PROVIDER: E-MTAB-12744 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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