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MBains PAO1 cprR (CP28)

ABSTRACT: Micoarrays were used to obtain gene expression in mid-log phase PAO1::cprR(PA3077) with the treatment of 12ug/ml CP28 vs mid-log phase PAO1 with the treatment of 12ug/ml CP28

ORGANISM(S): Pseudomonas aeruginosa PAO1

SUBMITTER: Manjeet Bains

PROVIDER: E-MTAB-1276 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS.

Fernández Lucía L Jenssen Håvard H Bains Manjeet M Wiegand Irith I Gooderham W James WJ Hancock Robert E W RE

Antimicrobial agents and chemotherapy 20120924 12

Cationic antimicrobial peptides pass across the outer membrane by interacting with negatively charged lipopolysaccharide (LPS), leading to outer membrane permeabilization in a process termed self-promoted uptake. Resistance can be mediated by the addition of positively charged arabinosamine through the action of the arnBCADTEF operon. We recently described a series of two-component regulators that lead to the activation of the arn operon after recognizing environmental signals, including low-Mg( ...[more]

PMID: 23006746

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