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RNAseq of subepithelial connective tissue grafts obtained at different location and depth in the human palate

ABSTRACT: Aim: Identify set of genes, whose expression is dependent on the graft location in the patient’s palate (anterior vs. posterior) and depth of harvest (superficial vs. deep). The mRNA-Seq contains 64 human samples. The samples represent connective tissue grafts (CTGs) harvested at different locations (anterior and posterior) and different depths (superficial and deep) in the patient’s palate. Thus, we have 4 groups with 16 samples per group: asCTGs (anterior superficial) – 16 samples adCTGs (anterior deep) – 16 samples psCTGs (posterior superficial) – 16 samples pdCTGs (posterior deep) – 16 samples

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Geert van Geest

PROVIDER: E-MTAB-13141 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential molecular profiles and associated functionalities characterize connective tissue grafts obtained at different locations and depths in the human palate.

Asparuhova Maria B MB Song Xiaoqing X Riedwyl Dominic D van Geest Geert G Bosshardt Dieter D DD Sculean Anton A

International journal of oral science 20231211 1

The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts (CTGs) obtained at different locations and depths in the human palate. Sixty-four CTGs belonging to anterior deep (AD), anterior superficial (AS), posterior deep (PD), and posterior superficial (PS) groups were subjected to RNA-Sequencing and their transcriptomes were analyzed computationally. Functional correlations characterizing the CTG groups were validated by cell biological experiments using ...[more]

PMID: 38072943

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