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Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiling of human gastric tumors and adjacent non-cancerous mucosa

ABSTRACT: Gastric cancer is a heterogeneous disease. The molecular mechanism behind the development of gastric cancer and the different histological subtypes, are yet not completely clear. A better understanding of this may result in better prevention, early diagnosis and treatment strategies. In this study we analyzed gene expression in tumor, adjacent non-cancerous mucosa biopsies and in age/sex matched samples from healthy individuals.

ORGANISM(S): Homo sapiens

SUBMITTER: Arnar Flatberg

PROVIDER: E-MTAB-1338 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Denervation suppresses gastric tumorigenesis.

Zhao Chun-Mei CM Hayakawa Yoku Y Kodama Yosuke Y Muthupalani Sureshkumar S Westphalen Christoph B CB Andersen Gøran T GT Flatberg Arnar A Johannessen Helene H Friedman Richard A RA Renz Bernhard W BW Sandvik Arne K AK Beisvag Vidar V Tomita Hiroyuki H Hara Akira A Quante Michael M Li Zhishan Z Gershon Michael D MD Kaneko Kazuhiro K Fox James G JG Wang Timothy C TC Chen Duan D

Science translational medicine 20140801 250

The nervous system plays an important role in the regulation of epithelial homeostasis and has also been postulated to play a role in tumorigenesis. We provide evidence that proper innervation is critical at all stages of gastric tumorigenesis. In three separate mouse models of gastric cancer, surgical or pharmacological denervation of the stomach (bilateral or unilateral truncal vagotomy, or local injection of botulinum toxin type A) markedly reduced tumor incidence and progression, but only in ...[more]

PMID: 25143365

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