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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNAseq of scalp biopsies from EGFRi treated patients, who exhibited a folliculitis

ABSTRACT: EGFR/MEK inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of hair follicle immune privilege and differential modulation of IL-33 and IL-37 expression. Our findings suggest that successful future management of EGFRi/MEKi-induced folliculitis requires restoration of hair follicle immune privilege. In this RNAseq parietal scalp (rather than truncal skin) biopsies were taken from long-term (3-9 months) EGFRi-treated patients exhibiting folliculitis (Chronic-EGFRi) or from patients prior to commencing and after two weeks of EGFRi therapy (Acute-EGFRi), compared to normal scalp skin.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Rachel Scholey

PROVIDER: E-MTAB-13455 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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