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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Epigenetic regulation of reactivation of the silenced X-chromosome during mouse germline development

ABSTRACT: X chromosome reactivation (XCR) occurs over a prolonged period during genome-wide reprogramming in female germ cells, initiating soon after primordial germ cell specification. The kinetics of XCRs remain poorly understood, as previous studies of XCR were based on a few genes. For a global appraisal of the regulation of XCR dynamics, we performed matched CUT&RUN for H3K27me3 and H2AK119ub1 on F1 female (XX(Xist∆)) germ cells at E13.5 and E16.5 stages during embryonic development.

INSTRUMENT(S): NextSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Mahesh Sangrithi

PROVIDER: E-MTAB-13576 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Reactivation of the silenced X-chromosome during mouse germline development

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