Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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DEAD-box ATPase Dbp2 mediates mRNA release after 3’-end formation


ABSTRACT: DEAD-box ATPases belong to an abundant class of proteins that are involved in virtually all aspects of RNA metabolism and are found in all kingdoms of life. When bound to a DEAD-box ATPase, the RNA substrate is forced into a kinked conformation that is incompatible with helical structures. Distortion of the RNA can result in unwinding of short RNA duplexes (helicase activity) or destabilize RNA-protein interactions, allowing DEAD-box ATPases to remodel mRNPs (RNPase activity). The RNPase activity makes DEAD-box ATPases suitable molecular building blocks for the implementation of checkpoints that confer directionality to the process of RNA biogenesis. Here, we provide data that characterizes the DEAD-box ATPase Dbp2 (SPBP8B7.16c) of the fission yeast Schizosaccharomyces pombe. Using ChIP-seq, we determined the sites where HTP-tagged Dbp2 associates with chromatin. ChIP-seq of Srp2-HTP is included as a reference protein that is known to associate with transcribing RNA polymerase II (RNAPII).

INSTRUMENT(S): NextSeq 2000

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Cornelia Kilchert 

PROVIDER: E-MTAB-13712 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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