Comprehensive Transcriptomic Analysis of NSC34 Motor Neurons following TDP43 Modulation: Knockdown vs. Control and Wild Type vs. TDP43 M337V Mutation

ABSTRACT: Transactive response DNA binding protein of 43 kDa (TDP43) is a ribonucleoprotein integral to several neurodegenerative diseases. Under normal conditions, TDP43 primarily localizes in the nucleus, where it plays a crucial role in RNA metabolism. Its function necessitates shuttling between the nucleus and cytoplasm. TDP43 dysfunction plays a significant role in the pathogenesis of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer's disease (AD), and Parkinson’s disease. A common dysfunction of TDP43 is nuclear depletion and cytoplasmic aggregation of the protein. Additionally, aggregation-prone mutations, such as the TDP43M337V mutation, exacerbate TDP43 mislocalization to the cytoplasm, increasing neuronal toxicit

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER:  

PROVIDER: E-MTAB-13738 | biostudies-arrayexpress |

SECONDARY ACCESSION(S): ERP156983

REPOSITORIES: biostudies-arrayexpress