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Microarray expression analysis of bevacizumab-resistant glioblastomas compared to pre-treatment paired specimens

ABSTRACT: Paired samples of resected tumor from glioblastoma patients: Pre and post Avastin-treatment samples for each patient in the cohort.

ORGANISM(S): Homo sapiens

SUBMITTER: Taku Tokuyasu

PROVIDER: E-MTAB-1380 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance.

Jahangiri Arman A De Lay Michael M Miller Liane M LM Carbonell W Shawn WS Hu Yu-Long YL Lu Kan K Tom Maxwell W MW Paquette Jesse J Tokuyasu Taku A TA Tsao Sean S Marshall Roxanne R Perry Arie A Bjorgan Kirsten M KM Chaumeil Myriam M MM Ronen Sabrina M SM Bergers Gabriele G Aghi Manish K MK

Clinical cancer research : an official journal of the American Association for Cancer Research 20130110 7

<h4>Purpose</h4>To identify mediators of glioblastoma antiangiogenic therapy resistance and target these mediators in xenografts.<h4>Experimental design</h4>We conducted microarray analysis comparing bevacizumab-resistant glioblastomas (BRG) with pretreatment tumors from the same patients. We established novel xenograft models of antiangiogenic therapy resistance to target candidate resistance mediator(s).<h4>Results</h4>BRG microarray analysis revealed upregulation versus pretreatment of recept ...[more]

PMID: 23307858

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