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Ring1b profiling in pancreatic islets

ABSTRACT: To gain insights into how pancreatic cells are programmed in vivo, we profiled Ring1b in embryonic stem cells and pancreatic islets

ORGANISM(S): Mus musculus

SUBMITTER: joris van arensbergen

PROVIDER: E-MTAB-1402 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells.

van Arensbergen Joris J García-Hurtado Javier J Maestro Miguel Angel MA Correa-Tapia Miguel M Rutter Guy A GA Vidal Miguel M Ferrer Jorge J

Genes & development 20121227 1

Polycomb-mediated gene repression is essential for embryonic development, yet its precise role in lineage-specific programming is poorly understood. Here we inactivated Ring1b, encoding a polycomb-repressive complex 1 subunit, in pancreatic multipotent progenitors (Ring1b(progKO)). This caused transcriptional derepression of a subset of direct Ring1b target genes in differentiated pancreatic islet cells. Unexpectedly, Ring1b inactivation in differentiated islet β cells (Ring1b(βKO)) did not caus ...[more]

PMID: 23271347

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