Primary human CD34+ cells for modeling ETO2-GLIS2 leukemogenesis - Bulk RNAseq
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ABSTRACT: Several fusion oncogenes showing a higher incidence in pediatric acute myeloid leukemia are associated with heterogeneous megakaryoblastic and other myeloid features. Here we addressed how developmental mechanisms influence human leukemogenesis by ETO2::GLIS2, a hallmark of dismal prognosis. We induced expression of ETO2::GLIS2 in primary human fetal and cord blood CD34+ hematopoietic cells and obtained bulk transcriptomes after in vitro cultures or in vivo engraftment and leukemia development in immunodeficient recipients (NSG or NSG-SGM3=NSG-S).
INSTRUMENT(S): Illumina NovaSeq 6000
ORGANISM(S): Homo sapiens
SUBMITTER: Thomas MERCHER
PROVIDER: E-MTAB-14131 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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