Characteristics of gene expression in epicardial adipose tissue and subcutaneous adipose tissue in patients at risk for heart failure undergoing coronary artery bypass grafting
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ABSTRACT: The study aimed to uncover the biological significance of epicardial adipose tissue (EAT) in heart failure (HF) development by comparing its gene expression to that of subcutaneous adipose tissue (SAT). Tissue samples were collected from 21 patients undergoing coronary artery bypass graft surgery to analyze differences in gene expression. The research further explored the relationships between these tissues in individuals categorized into different HF risk levels—specifically HF stage A (n=12) and pre-HF stage B (n=9). Analysis identified distinct gene expression profiles between EAT and SAT, revealing 17 gene clusters in EAT associated with characteristics of HF. These clusters were evaluated for their correlation with clinical HF markers to highlight their potential influence on heart function and disease progression. Raw data files are to be found on https://fega.nbis.se/ a few months after this publication.
INSTRUMENT(S): Illumina NovaSeq 6000
ORGANISM(S): Homo sapiens
SUBMITTER: Christoffer Frisk
PROVIDER: E-MTAB-14321 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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