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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq comparing the WT mouse hearts versus Dhx36 cKO hearts

ABSTRACT: This experiment aimed to investigate the transcriptional role of G4 resolvase Dhx36 in the adult mouse heart. We compared three pools of wild-type (WT) mouse hearts with three pools of Dhx36 conditional knockout (cKO) hearts. In the mutant mice, Dhx36 was conditionally deleted in cardiomyocytes using the Myh6-cre transgenic line. Each of the six pools was created using RNA extracted from 3-5 hearts from mice aged approximately 21 days. The cKO mice developed dilated cardiomyopathy and began experiencing sudden death at 40 days old, with no mutants surviving beyond 5 months.

INSTRUMENT(S): Illumina Genome Analyzer II

ORGANISM(S): Mus musculus

SUBMITTER: Pablo Gómez-del Arco

PROVIDER: E-MTAB-14440 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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