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Differential expression of S. coelicolor M145 vs. an abrC3 mutant in NB

ABSTRACT: Differential expression data set of S. coelicolor M145 and a abrC3 mutant cultured in NB. RNA samples were collected at 36, 48 and 60 hours following cDNA synthesis and labeling. The hybridization was conducted using DNA 104K microarrays (Surrey) using gDNA from S. coelicolor M145 as reference.

ORGANISM(S): Streptomyces coelicolor A3(2)

SUBMITTER: Emma Laing

PROVIDER: E-MTAB-1453 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deciphering the regulon of Streptomyces coelicolor AbrC3, a positive response regulator of antibiotic production.

Rico Sergio S Santamaría Ramón I RI Yepes Ana A Rodríguez Héctor H Laing Emma E Bucca Giselda G Smith Colin P CP Díaz Margarita M

Applied and environmental microbiology 20140207 8

The atypical two-component system (TCS) AbrC1/C2/C3 (encoded by SCO4598, SCO4597, and SCO4596), comprising two histidine kinases (HKs) and a response regulator (RR), is crucial for antibiotic production in Streptomyces coelicolor and for morphological differentiation under certain nutritional conditions. In this study, we demonstrate that deletion of the RR-encoding gene, abrC3 (SCO4596), results in a dramatic decrease in actinorhodin (ACT) and undecylprodiginine (RED) production and delays morp ...[more]

PMID: 24509929

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