IGR_IsabellePLO_MPN_IPS
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Bastien Job
PROVIDER: E-MTAB-1494 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients.
Saliba Joseph J Hamidi Sofiane S Lenglet Gaëlle G Langlois Thierry T Yin Jingkui J Cabagnols Xénia X Secardin Lise L Legrand Céline C Galy Anne A Opolon Paule P Benyahia Baya B Solary Eric E Bernard Olivier A OA Chen Longyun L Debili Najet N Raslova Hana H Norol Françoise F Vainchenker William W Plo Isabelle I Di Stefano Antonio A
PloS one 20130916 9
JAK2(V617F) is the predominant mutation in myeloproliferative neoplasms (MPN). Modeling MPN in a human context might be helpful for the screening of molecules targeting JAK2 and its intracellular signaling. We describe here the derivation of induced pluripotent stem (iPS) cell lines from 2 polycythemia vera patients carrying a heterozygous and a homozygous mutated JAK2(V617F), respectively. In the patient with homozygous JAK2(V617F), additional ASXL1 mutation and chromosome 20 allowed partial de ...[more]
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