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Baker_Stem_Cells

ABSTRACT: Gene expression studies of human embryonic stem cells undergoing directed differentiation to endothelial cells to identify key transcriptional changes during differentiation

ORGANISM(S): Homo sapiens

SUBMITTER: Martin McBride

PROVIDER: E-MTAB-1510 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment.

Howard Lynsey L Mackenzie Ruth M RM Pchelintsev Nikolay A NA McBryan Tony T McClure John D JD McBride Martin W MW Kane Nicole M NM Adams Peter D PD Milligan Graeme G Baker Andrew H AH

Stem cell research & therapy 20130424 2

<h4>Introduction</h4>Differentiation of vascular endothelial cells (ECs) in clinically relevant numbers for injection into ischaemic areas could offer therapeutic potential in the treatment of cardiovascular conditions, including myocardial infarction, peripheral vascular disease and stroke. While we and others have demonstrated successful generation of functional endothelial-like cells from human embryonic stem cells (hESCs), little is understood regarding the complex transcriptional and epigen ...[more]

PMID: 23618383

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