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Repression of arginase 2 expression in dendritic cells by microRNA-155 is critical for promoting T-cell proliferation

ABSTRACT: Microarray experiments were performed to compare the gene expression profiles exhibited by immature and activated bone-marrow (BM) derived conventional DCs (BM-cDCs) and plasmacytoid DCs (BM-pDCs) from WT and miR155-/- mice. (time points 0, 4 and 24 hours)

ORGANISM(S): Mus musculus

SUBMITTER: Olivier Schaad

PROVIDER: E-MTAB-1527 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Repression of arginase-2 expression in dendritic cells by microRNA-155 is critical for promoting T cell proliferation.

Dunand-Sauthier Isabelle I Irla Magali M Carnesecchi Stéphanie S Seguín-Estévez Queralt Q Vejnar Charles E CE Zdobnov Evgeny M EM Santiago-Raber Marie-Laure ML Reith Walter W

Journal of immunology (Baltimore, Md. : 1950) 20140709 4

Arginine, a semiessential amino acid implicated in diverse cellular processes, is a substrate for two arginases-Arg1 and Arg2-having different expression patterns and functions. Although appropriately regulated Arg1 expression is critical for immune responses, this has not been documented for Arg2. We show that Arg2 is the dominant enzyme in dendritic cells (DCs) and is repressed by microRNA-155 (miR155) during their maturation. miR155 is known to be strongly induced in various mouse and human D ...[more]

PMID: 25009204

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