Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Maria Rius
PROVIDER: E-MTAB-1529 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hummel-Eisenbeiss Johanna J Hascher Antje A Hals Petter-Arnt PA Sandvold Marit Liland ML Müller-Tidow Carsten C Lyko Frank F Rius Maria M
Molecular pharmacology 20130628 3
The nucleoside analog 5-azacytidine is an archetypical drug for epigenetic cancer therapy, and its clinical effectiveness has been demonstrated in the treatment of myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML). However, therapy resistance in patients with MDS/AML remains a challenging issue. Membrane proteins that are involved in drug uptake are potential mediators of drug resistance. The responsible proteins for the transport of 5-azacytidine into MDS/AML cells are unknow ...[more]