Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Nianshu Zhang
PROVIDER: E-MTAB-1550 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhang Nianshu N Quan Zhenzhen Z Rash Bharat B Oliver Stephen G SG
Open biology 20130522 5
The proteasome has been implicated in gene transcription through a variety of mechanisms. How the proteasome regulates genome-wide transcription in relation to nutrient signalling pathways is largely unknown. Using chemical inhibitors to compromise the functions of the proteasome and/or TORC1, we reveal that the proteasome and TORC1 synergistically promote the expression of de novo purine and amino acid biosynthetic genes, and restrict the transcription of those associated with proteolysis, star ...[more]