Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcriptional profiling of rats treated with VX-765 and Anakinra

ABSTRACT: Various studies showed a significant production/release of IL-1 beta following status epilepticus (SE) and during epileptogenesis. We studied the role of this cytokine in the epileptogenic process by blocking its production and downstream effects in vivo in a model of acquired epilepsy following SE induction. We used a pharmacological strategy consisting of the administration of two drugs, namely VX-765 and Anakinra, which selectively block the biosynthesis and the receptor type 1 of this cytokine, respectively.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Luca Beltrame

PROVIDER: E-MTAB-1567 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy.

Noe F M FM Polascheck N N Frigerio F F Bankstahl M M Ravizza T T Marchini S S Beltrame L L Banderó C Reschke CR Löscher W W Vezzani A A

Neurobiology of disease 20130809

We studied whether pharmacological blockade of the IL-1β-mediated signaling, rapidly activated in forebrain by epileptogenic injuries, affords neuroprotection in two different rat models of status epilepticus (SE). As secondary outcome, we measured treatment's effect on SE-induced epileptogenesis. IL-1β signaling was blocked by systemic administration of two antiinflammatory drugs, namely human recombinant IL-1 receptor antagonist (anakinra), the naturally occurring and clinically used competiti ...[more]

PMID: 23938763

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Dataset Information

Transcriptional profiling of rats treated with VX-765 and Anakinra

Publications

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy.

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