Type 2 diabetes-induced molecular and functional impairment of adipose tissue-derived mesenchymal stromal cells (ASCs) and interferon gamma priming for enhanced diabetic ASC-based therapy

ABSTRACT: Study Description: The study identified significant transcriptomic changes associated with T2D in human adipose stromal cells (hASCs) at basal level or after ASC treatment with a mix of proiflammatory cyokines (IFN-γ and TNF-α) for 48 hours. The microarray study comprised four main comparative groups. Group (Gp)1 focused on analyzing the transcriptome profiles of ASCs f from T2D patients (dASCs) with a BMI range from 25-29 kg/m², relative to ndASCs, from healthy donors matched for BMI range. Gp2 included an expanded cohort of T2D patients with a broader BMI range of 25-35 kg/m² (n=8), compared to a corresponding group of healthy donors (n=7). This design enabled focused assessment of transcriptomic variations associated with T2D, excluding the obesity as confounding factor, while also v

ORGANISM(S): Homo sapiens

SUBMITTER: Marwa Elshahat 

PROVIDER: E-MTAB-16267 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress