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Gene expressionprofiling of breast cell lines

ABSTRACT: We performed gene expression profiling of 31 breast cell lines (BCL) using whole-genome DNA microarrays (Affymetrix U133+2.0) to assessed a better molecular characterization of breast cell lines in order to help discover of new markers to apply to tumour samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Pascal Finetti

PROVIDER: E-MTAB-1693 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling of breast cell lines identifies potential new basal markers.

Charafe-Jauffret E E Ginestier C C Monville F F Finetti P P Adélaïde J J Cervera N N Fekairi S S Xerri L L Jacquemier J J Birnbaum D D Bertucci F F

Oncogene 20060401 15

A better molecular characterization of breast cell lines (BCL) may help discover new markers to apply to tumour samples. We performed gene and protein expression profiling of 31 BCL using whole-genome DNA microarrays and immunohistochemistry (IHC) on 'cell microarrays' (CMA), respectively. Global hierarchical clustering discriminated two groups of BCL: group I corresponded to luminal cell lines, group II to basal and mesenchymal cell lines. Correlations with centroids calculated from a published ...[more]

PMID: 16288205

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