Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina Genome Analyzier Iix
ORGANISM(S): Homo sapiens
SUBMITTER: Florian Finkernagel
PROVIDER: E-MTAB-1731 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Stielow Christina C Stielow Bastian B Finkernagel Florian F Scharfe Maren M Jarek Michael M Suske Guntram G
Nucleic acids research 20131224 5
Lethal(3) malignant brain tumour like 2 (L3MBTL2) is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. Here, we show that L3MBTL2 is modified by SUMO2/3 at lysine residues 675 and 700 close to the C-terminus. SUMOylation of L3MBTL2 neither affected its repressive activity in reporter gene assays nor it's binding to histone tails in vitro. In order to analyse whether SUMOylation affects binding of ...[more]