PHH Chlorpromazine
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Germaine Truisi
PROVIDER: E-MTAB-1747 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptomic hepatotoxicity signature of chlorpromazine after short- and long-term exposure in primary human sandwich cultures.
Parmentier Céline C Truisi Germaine L GL Moenks Konrad K Stanzel Sven S Lukas Arno A Kopp-Schneider Annette A Alexandre Eliane E Hewitt Philip G PG Mueller Stefan O SO Richert Lysiane L
Drug metabolism and disposition: the biological fate of chemicals 20130802 10
Drug-induced liver injury is the most frequent reason for market withdrawal of approved drugs, and is difficult to predict in animal models. Here, we analyzed transcriptomic data derived from short- and long-term cultured primary human hepatocytes (PHH) exposed to the well known human hepatotoxin chlorpromazine (CPZ). Samples were collected from five PHH cultures after short-term (1 and 3 days) and long-term (14 days) repeat daily treatment with 0.1 or 0.2 µM CPZ, corresponding to C(max). Two PH ...[more]
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