Transcription profiling by array of mouse primary Cyp27b1 knockout skin fibroblasts regulated by vitamin D3 metabolites
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yan-Ru Lou
PROVIDER: E-MTAB-1774 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression profiles in human and mouse primary cells provide new insights into the differential actions of vitamin D3 metabolites.
Tuohimaa Pentti P Wang Jing-Huan JH Khan Sofia S Kuuslahti Marianne M Qian Kui K Manninen Tommi T Auvinen Petri P Vihinen Mauno M Lou Yan-Ru YR
PloS one 20131008 10
1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3) had earlier been regarded as the only active hormone. The newly identified actions of 25-hydroxyvitamin D3 (25(OH)D3) and 24R,25-dihydroxyvitamin D3 (24R,25(OH)2D3) broadened the vitamin D3 endocrine system, however, the current data are fragmented and a systematic understanding is lacking. Here we performed the first systematic study of global gene expression to clarify their similarities and differences. Three metabolites at physiologically comparable l ...[more]
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