Differential effects of antofine N-oxide on solid tumor and leukemia cells

ABSTRACT: We have studied the anti-cancer activities of antofine N-oxide isolated and purified from the medicinal plant Cynanchum vincetoxicum. The compound displays a strong cytotoxic effect on several solid tumor cell lines (glioblastoma, breast carcinoma and lung carcinoma) and on T-cell leukemia. It induces cytostasis in the solid tumor cell lines whereas it causes apoptotic cell death in the leukemia cell line. The cytotoxic effect is much weaker in non-cancer control cells. A microarray analysis of the gene expression after a short treatment showed a set of differentially expressed genes in the two types of cancer cells (apoptosis versus cytostasis). Interestingly, a number of genes of the TNF-alpha signaling pathway are up-regulated in the three solid tumor cell lines, including TNF-alpha whi

ORGANISM(S): Homo sapiens

SUBMITTER: Arnaud Muller 

PROVIDER: E-MTAB-1900 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress