Ontology highlight
ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Sameet Mehta
PROVIDER: E-MTAB-1962 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lee Nathan N NN Chalamcharla Venkata R VR Reyes-Turcu Francisca F Mehta Sameet S Zofall Martin M Balachandran Vanivilasini V Dhakshnamoorthy Jothy J Taneja Nitika N Yamanaka Soichiro S Zhou Ming M Grewal Shiv I S SI
Cell 20131107 5
The regulation of protein-coding and noncoding RNAs is linked to nuclear processes, including chromatin modifications and gene silencing. However, the mechanisms that distinguish RNAs and mediate their functions are poorly understood. We describe a nuclear RNA-processing network in fission yeast with a core module comprising the Mtr4-like protein, Mtl1, and the zinc-finger protein, Red1. The Mtl1-Red1 core promotes degradation of mRNAs and noncoding RNAs and associates with different proteins to ...[more]