Unknown,Transcriptomics,Genomics,Proteomics

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Setdb2 knockdown microarray


ABSTRACT: As the primary driving forces of gastrulation, convergence and extension (C&E) movements lead to a medio-lateral narrowing and an anterior-posterior elongation of the embryonic body axis. Histone methylation as a post-translational modification plays a critical role for early embryonic development, but its functions on C&E movements remaine largely unknown. Here, we uncover that knockdown of setdb2, a SET domain-containing protein possessing potential histone H3K9 methyltransferase activity, induces abnormal C&E movements. Then, we perform genome-wide gene expression profiling of zebrafish in 6h control embryos and setdb2 morphant embryos to address the downstream target of setdb2 gene.

ORGANISM(S): Danio rerio

SUBMITTER: Ting-Ting Du 

PROVIDER: E-MTAB-2207 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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