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Aerobic v. anaerobic gene expression in Aggregatibacter actinomycetemcomitans

ABSTRACT: The opportunistic pathogen A. actinomycetemcomitans (Aa) expereinces fluctuating oxygen levels in its natural habitat, the gingival crevice of the human oral cavity. Since oxygen influences metabolic interactions between Aa and other oral microbes, we sought to characterize oxygen-dependent Aa gene expression.

ORGANISM(S): Aggregatibacter actinomycetemcomitans

SUBMITTER: Apollo Stacy

PROVIDER: E-MTAB-2213 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Bacterial fight-and-flight responses enhance virulence in a polymicrobial infection.

Stacy Apollo A Everett Jake J Jorth Peter P Trivedi Urvish U Rumbaugh Kendra P KP Whiteley Marvin M

Proceedings of the National Academy of Sciences of the United States of America 20140513 21

The oral pathogen Aggregatibacter actinomycetemcomitans (Aa) resides in infection sites with many microbes, including commensal streptococci such as Streptococcus gordonii (Sg). During infection, Sg promotes the virulence of Aa by producing its preferred carbon source, l-lactate, a phenomenon referred to as cross-feeding. However, as with many streptococci, Sg also produces high levels of the antimicrobial hydrogen peroxide (H2O2), leading to the question of how Aa deals with this potent antimic ...[more]

PMID: 24825893

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