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Breast cancer cell lines ALDH+/-

ABSTRACT: Self-renewal and differentiation are two epigenetic programs that regulate pluripotency of stem cells. During oncogenesis, dysregulation of these two programs leads to the development of cancer stem cells (CSCs). Here, we used a pan genomic promoter microarray to determine the DNA methylation portrait of breast cancer stem cells (bCSC) compared to non-bCSC

ORGANISM(S): Homo sapiens

SUBMITTER: Arnaud Guille

PROVIDER: E-MTAB-2236 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Brief reports: A distinct DNA methylation signature defines breast cancer stem cells and predicts cancer outcome.

El Helou Rita R Wicinski Julien J Guille Arnaud A Adélaïde Jose J Finetti Pascal P Bertucci François F Chaffanet Max M Birnbaum Daniel D Charafe-Jauffret Emmanuelle E Ginestier Christophe C

Stem cells (Dayton, Ohio) 20141101 11

Self-renewal and differentiation are two epigenetic programs that regulate stem cells fate. Dysregulation of these two programs leads to the development of cancer stem cells (CSCs). Recent evidence suggests that CSCs are relatively resistant to conventional therapies and responsible for metastasis formation. Deciphering these processes will help understand oncogenesis and allow the development of new targeted therapies. Here, we have used a whole genome promoter microarray to establish the DNA m ...[more]

PMID: 25069843

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