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KK_Arhgap28

ABSTRACT: Microarray comparison of gene expression between bone tissues of wild type and Arhga28del mice

ORGANISM(S): Mus musculus

SUBMITTER: Leo Leo Zeef

PROVIDER: E-MTAB-2296 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers.

Yeung Ching-Yan Chloé CY Taylor Susan H SH Garva Richa R Holmes David F DF Zeef Leo A LA Soininen Raija R Boot-Handford Raymond P RP Kadler Karl E KE

PloS one 20140911 9

The small GTPase RhoA is a major regulator of actin reorganization during the formation of stress fibers; thus identifying molecules that regulate Rho activity is necessary for a complete understanding of the mechanisms that determine cell contractility. Here, we have identified Arhgap28 as a Rho GTPase activating protein (RhoGAP) that switches RhoA to its inactive form. We generated an Arhgap28-LacZ reporter mouse that revealed gene expression in soft tissues at E12.5, pre-bone structures of th ...[more]

PMID: 25211221

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