CIC inactivating mutations are associated with poor prognosis and increased proliferation pathways
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ABSTRACT: A better understanding of oligodendroglioma biology is needed to develop new specific targeted therapies. We show here that CIC mutations are associated with negative outcome and upregulation of proliferative pathways. Our data also suggest that CIC mutations result in CIC inactivation. Finally our data suggest a synergistic negative impact of the CIC mutations and P16 alterations on survival, pointing out to CyclinD1 as key effector of oligodendrogliomas.
ORGANISM(S): Homo sapiens
SUBMITTER: Vincent Gleize
PROVIDER: E-MTAB-2358 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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