Dataset Information
Systems biology approaches reveal low-dose effects of nanoparticles
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500, Computater Servers UPPMAX-SNIC., NanoDrop spectrophotometer (NanoDrop Technologies, Wilmington, DE), Dynamic light scattering and zeta potential. The experiments were performed on a Malvern Zetasizer NanoZS instrument using a He-Ne laser (Max, 5 mW) at 633 nm., Illumina Tru-seq RNA
ORGANISM(S): Homo sapiens
SUBMITTER: Pekka Kohonen
PROVIDER: E-MTAB-2397 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Next-generation sequencing reveals low-dose effects of cationic dendrimers in primary human bronchial epithelial cells.
ACS nano 20141230 1
Gene expression profiling has developed rapidly in recent years with the advent of deep sequencing technologies such as RNA sequencing (RNA Seq) and could be harnessed to predict and define mechanisms of toxicity of chemicals and nanomaterials. However, the full potential of these technologies in (nano)toxicology is yet to be realized. Here, we show that systems biology approaches can uncover mechanisms underlying cellular responses to nanomaterials. Using RNA Seq and computational approaches, w ...[more]
