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Unknown,Transcriptomics,Genomics,Proteomics

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Novel PAX5 fusion genes in childhood B-Cell Precursors Acute Lymphoblastic Leukemia

ABSTRACT: PAX5, a transcription factor essential for B-cell development, has been found as a frequent target of abnormalities in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) cases, showing point mutations, deletions, as well as translocations with several partner genes. We identified four novel PAX5 fusion partner genes by performing a screening on BCP-ALL cases with 9p rearrangements. Copy Number Variation analysis of translocated samples showed that few significant cooperative genetic lesions are present in addition to the translocation event, suggesting that it might have a primary role in leukemogenesis.

INSTRUMENT(S): Affymetrix Fluidics Station

ORGANISM(S): Homo sapiens

SUBMITTER: Grazia Fazio

PROVIDER: E-MTAB-2416 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Three novel fusion transcripts of the paired box 5 gene in B-cell precursor acute lymphoblastic leukemia.

Fazio Grazia G Daniele Giulia G Cazzaniga Valeria V Impera Luciana L Severgnini Marco M Iacobucci Ilaria I Galbiati Marta M Leszl Anna A Cifola Ingrid I De Bellis Gianluca G Bresciani Paola P Martinelli Giovanni G Basso Giuseppe G Biondi Andrea A Storlazzi Clelia Tiziana CT Cazzaniga Giovanni G

Haematologica 20141010 1

PMID: 25304615

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